Br J Psychiatry. 1988 Sep;153:387-9.

Post-partum psychosis in adult GM2 gangliosidosis. A case report.

Lichtenberg P, Navon R, Wertman E, Dasberg H, Lerer B.

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Department of Psychiatry, Jerusalem Mental Health Center.

Abstract

Adult hexosaminidase A deficiency is a form of GM2 gangliosidosis with autosomal recessive inheritance. Only 35 cases (mostly among Ashkenazic Jews) have been reported worldwide. Symptoms include, in a third of the cases, psychosis. A 27-year-old sufferer with no prior psychiatric history, developed a post-partum psychosis, with affective and hebephrenic components, 3 days following her first delivery. She responded to lithium within 10 days of initiating treatment; the full episode lasted 1 month. We conclude that lithium is the preferred treatment for psychosis in such adult patients, especially in light of possible long-term neurological deterioration caused by phenothiazines. Ashkenazic Jews with atypical neurological syndromes presenting with psychosis should be tested for hexosaminidase A deficiency.

PMID:: 2977954; [PubMed - indexed for MEDLINE]

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Post-partum psychosis in adult GM2 gangliosidosis. A case report.
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Post-partum psychosis in adult GM2 gangliosidosis. A case report.

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