Neurons Are the Inflammatory Problem

Kevin J Tracey

doi:10.1016/j.cell.2018.05.005

Neurons Are the Inflammatory Problem

Cell. 2018 May 17;173(5):1066-1068. doi: 10.1016/j.cell.2018.05.005.

Author

Kevin J Tracey¹

Affiliation

¹ Feinstein Institute for Medical Research, Manhasset, New York, USA. Electronic address: KJTracey@northwell.edu.

PMID: 29775588
DOI: 10.1016/j.cell.2018.05.005

Abstract

The discovery that reflex neuronal circuits control immunity provided a new mechanistic understanding of infection and injury. Pinho-Ribeiro et al. (2018) report that lethal tissue destruction from streptococcal necrotizing fasciitis ("flesh-eating disease") occurs because sensory neurons reflexively inhibit frontline immune responses.

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MeSH terms

Fasciitis, Necrotizing*
Humans
Neurons
Streptococcal Infections*