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    Pediatr Neurol. 1987 Mar-Apr;3(2):83-6.

    Reduction of elevated CSF beta-endorphin by fenfluramine in infantile autism.

    Ross DL, Klykylo WM, Hitzemann R.

    Source

    Department of Neurology, University of Cincinnati, Ohio.

    Abstract

    Fenfluramine therapy has been reported to improve behavior in infantile autism and has been associated with a decrease in abnormally increased blood serotonin content. The primary central effect has not been proved to be serotonergic. Beta-endorphin is involved in the anorexic effect of fenfluramine and may play a role in autism. Nine children with infantile autism were treated with fenfluramine in double-blind, placebo-crossover design. Transient anorexia was the only adverse effect. Autistic behavior was reported to improve in three patients, but objective psychometric tests were unchanged. Beta-endorphin-like immunoreactivity was determined in lumbar cerebrospinal fluid of patients during and before or after treatment with fenfluramine and then was compared to normal controls. Beta-endorphin was elevated significantly in the baseline autistic group (p less than .005) and was reduced toward control values during fenfluramine treatment. The results are consistent with a role for beta-endorphin in infantile autism and in the mechanism of fenfluramine treatment.

    PMID:
    2977280
    [PubMed - indexed for MEDLINE]

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