High incidence of BRAF V600 mutation in Indian patients with head and neck cancer

Ashna Gauthaman; Anbalagan Moorthy

doi:10.2741/E838

High incidence of BRAF V600 mutation in Indian patients with head and neck cancer

Front Biosci (Elite Ed). 2018 Jun 1;10(3):520-527. doi: 10.2741/E838.

Authors

Ashna Gauthaman¹, Anbalagan Moorthy²

Affiliations

¹ Department of Integrative Biology, School of Bio Sciences and Technology, VIT University, Vellore, India 632014.
² Department of Integrative Biology, School of Bio Sciences and Technology, VIT University, Vellore, India 632014, anbalagan.m@vit.ac.in.

PMID: 29772524
DOI: 10.2741/E838

Abstract

In cancer cells, BRAF is frequently mutated at codon 600 (^V600) leading to the replacement of valine amino acid with other amino acids. The current study was performed to assess the prevalence of BRAF^V600 mutation in Indian patients with head and neck squamous cell carcinoma (HNSCC). Among the patients, 27% were homozygous, and 71% were heterozygous for the mutation and only 2% showed a wild genotype. Since identification of BRAF^V600 mutation in cancer patients is used for selection of the therapeutic agents, this study shows that all Indian patients with HNSCCmust be screened for this mutation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Carcinoma, Squamous Cell / genetics*
Carcinoma, Squamous Cell / mortality
Female
Head and Neck Neoplasms / genetics*
Head and Neck Neoplasms / mortality
Humans
India / epidemiology
Male
Middle Aged
Mutation, Missense
Proto-Oncogene Proteins B-raf / genetics*

Substances

BRAF protein, human
Proto-Oncogene Proteins B-raf