Sevuparin blocks sickle blood cell adhesion and sickle-leucocyte rolling on immobilized L-selectin in a dose dependent manner

Br J Haematol. 2019 Mar;184(5):873-876. doi: 10.1111/bjh.15188. Epub 2018 May 16.

Authors

Jennell White^{1

2}, Maria Lindgren³, Ke Liu², Xiufeng Gao², Lena Jendeberg³, Patrick Hines^{1

2

4}

Affiliations

¹ Division of Pediatric Critical Care Medicine, Wayne State University School of Medicine, Detroit, MI, USA.
² Functional Fluidics, Detroit, MI, USA.
³ Modus Therapeutics, Stockholm, Sweden.
⁴ Department of Physiology, Wayne State University School of Medicine, Detroit, MI, USA.

PMID: 29767405
DOI: 10.1111/bjh.15188

No abstract available

Keywords: L-selectin; adhesion; anti-adhesive; low molecular weight heparin; sickle cell disease.

Publication types

Letter

MeSH terms

Adolescent
Adult
Anemia, Sickle Cell / metabolism*
Anemia, Sickle Cell / pathology
Cell Adhesion / drug effects
Dose-Response Relationship, Drug
Female
Heparin / analogs & derivatives*
Heparin / pharmacology
Human Umbilical Vein Endothelial Cells / metabolism*
Human Umbilical Vein Endothelial Cells / pathology
Humans
L-Selectin / metabolism*
Leukocyte Rolling / drug effects*
Leukocytes / metabolism*
Leukocytes / pathology
Male

Substances

L-Selectin
sevuparin
Heparin