Estimating the acute effects of fine and coarse particle pollution on stroke mortality of in six Chinese subtropical cities

Environ Pollut. 2018 Aug:239:812-817. doi: 10.1016/j.envpol.2018.04.102. Epub 2018 May 8.

Abstract

While increasing evidence suggested that PM2.5 is the most harmful fraction of the particle pollutants, the health effects of coarse particles (PM10-2.5) have been inconclusive, especially on cerebrovascular diseases, we thus evaluated the effects of PM10, PM2.5, and PM10-2.5 on stroke mortality in six Chinese subtropical cities using generalized additive models. We also conducted random-effects meta-analyses to estimate the overall effects across the six cities. We found that PM10, PM2.5, and PM10-2.5 were significantly associated with stroke mortality. Each 10 μg/m3 increase of PM10, PM2.5 and PM10-2.5 (lag03) was associated with an increase of 1.88% (95% CI: 1.37%, 2.39%), 3.07% (95% CI: 2.35%, 3.79%), and 5.72% (95% CI: 3.82%, 7.65%) in overall stroke mortality. Using the World Health Organization's guideline as reference concentration, we estimated that 3.21% (95% CI: 1.65%, 3.01%) of stroke mortality (corresponding to 1743 stroke mortalities, 95% CI: 896, 1633) were attributed to PM10, 5.57% (95% CI: 0.50%, 1.23%) stroke mortality (3019, 95% CI: 2286, 3777) were attributed to PM2.5, and 2.02% (95% CI: 1.85%, 3.08%) of stroke mortality (1097, 95% CI: 1005, 1673) could be attributed to PM10-2.5. Our analysis indicates that both PM2.5 and PM10-2.5 are important risk factors of stroke mortality and should be considered in the prevention and control of stroke in the study area.

Keywords: Air pollution; China; Particulate matter; Stroke.

MeSH terms

  • Air Pollutants / analysis*
  • China
  • Cities
  • Environmental Exposure / analysis*
  • Epidemiological Monitoring
  • Humans
  • Particle Size
  • Particulate Matter / analysis*
  • Risk Factors
  • Stroke / mortality*
  • Tropical Climate
  • World Health Organization

Substances

  • Air Pollutants
  • Particulate Matter