Clin Exp Immunol. 1988 Sep;73(3):456-60.

Anticardiolipin antibodies in systemic sclerosis: immunological and clinical associations.

Malia RG, Greaves M, Rowlands LM, Lawrence AC, Hume A, Rowell NR, Moult J, Holt CM, Lindsey N, Hughes P.

Source

Department of Haematology, Royal Hallamshire Hospital, Sheffield, UK.

Abstract

Anticardiolipin antibodies of IgG/IgM class were detected in seven of 28 patients with systemic sclerosis including five of 16 patients severely affected by extensive visceral disease. This severely affected sub-group also showed significant elevations of plasma levels of von Willebrand factor antigen in 10 cases and serum C1q binding activity in seven cases respectively. This triple association raises the possibility that multiple immunological mechanisms are involved in the pathogenesis of systemic sclerosis and its vascular lesions.

PMID:: 2974767; [PubMed - indexed for MEDLINE]
PMCID:: PMC1541778

Free PMC Article

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Related Immune Epitope Information - Immune Epitope Database and Analysis Resource

Supplemental Content

Save items

Related citations in PubMed

Platelet activation, endothelial cell dysfunction in the absence of anticardiolipin antibodies in systemic sclerosis. [J Rheumatol. 1991]
Platelet activation, endothelial cell dysfunction in the absence of anticardiolipin antibodies in systemic sclerosis.
Lima J, Fonollosa V, Fernández-Cortijo J, Ordi J, Cuenca R, Khamashta MA, Vilardell M, Simeón CP, Picó M. J Rheumatol. 1991 Dec; 18(12):1833-6.
Antibody-dependent cellular cytotoxicity of vascular endothelium: characterization and pathogenic associations in systemic sclerosis. [Clin Exp Immunol. 1989]
Antibody-dependent cellular cytotoxicity of vascular endothelium: characterization and pathogenic associations in systemic sclerosis.
Holt CM, Lindsey N, Moult J, Malia RG, Greaves M, Hume A, Rowell NR, Hughes P. Clin Exp Immunol. 1989 Dec; 78(3):359-65.
Anticardiolipin antibodies in patients with autoimmune diseases: isotype distribution and clinical associations. [Clin Rheumatol. 1989]
Anticardiolipin antibodies in patients with autoimmune diseases: isotype distribution and clinical associations.
Font J, Cervera R, Lopez-Soto A, Pallares L, Bosch X, Ampurdanes S, Casals FJ, Ingelmo M. Clin Rheumatol. 1989 Dec; 8(4):475-83.
Circulating immune complexes in patients with progressive systemic sclerosis. [Arthritis Rheum. 1982]
Circulating immune complexes in patients with progressive systemic sclerosis.
Siminovitch K, Klein M, Pruzanski W, Wilkinson S, Lee P, Yoon SJ, Keystone E. Arthritis Rheum. 1982 Oct; 25(10):1174-9.
Anticardiolipin antibodies in systemic lupus erythematosus. [Cleve Clin J Med. 1989]
Anticardiolipin antibodies in systemic lupus erythematosus.
Danao-Camara T, Clough JD. Cleve Clin J Med. 1989 Jul-Aug; 56(5):525-8.

See reviews... See all...

Cited by 8 PubMed Central articles

Review The clinical relevance of autoantibodies in scleroderma. [Arthritis Res Ther. 2003]
Review The clinical relevance of autoantibodies in scleroderma.
Ho KT, Reveille JD. Arthritis Res Ther. 2003; 5(2):80-93. Epub 2003 Feb 12.
Cutaneous manifestations associated with antiphospholipid antibodies in patients with suspected primary antiphospholipid syndrome: a case-control study. [Ann Rheum Dis. 1993]
Cutaneous manifestations associated with antiphospholipid antibodies in patients with suspected primary antiphospholipid syndrome: a case-control study.
Naldi L, Locati F, Marchesi L, Cortelazzo S, Finazzi G, Galli M, Brevi A, Cainelli T, Barbui T. Ann Rheum Dis. 1993 Mar; 52(3):219-22.
Vasculitis in patients with systemic sclerosis and severe digital ischaemia requiring amputation. [Ann Rheum Dis. 1994]
Vasculitis in patients with systemic sclerosis and severe digital ischaemia requiring amputation.
Herrick AL, Oogarah PK, Freemont AJ, Marcuson R, Haeney M, Jayson MI. Ann Rheum Dis. 1994 May; 53(5):323-6.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Anticardiolipin antibodies in systemic sclerosis: immunological and clinical ass...
Anticardiolipin antibodies in systemic sclerosis: immunological and clinical associations.
Clin Exp Immunol. 1988 Sep ;73(3):456-60.

PubMed
The determination of twin zygosity by means of a mailed questionnaire.
The determination of twin zygosity by means of a mailed questionnaire.
Acta Genet Med Gemellol (Roma). 1979 ;28(3):225-36.

PubMed
Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental...
Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA.
Science. 1988 Dec 9 ;242(4884):1430-3.

PubMed
Interaction of disulfiram with benzodiazepines.
Interaction of disulfiram with benzodiazepines.
Clin Pharmacol Ther. 1978 Nov ;24(5):583-9.

PubMed
[Immunoreactivity in ischemic heart disease of atherosclerotic etiology].
[Immunoreactivity in ischemic heart disease of atherosclerotic etiology].
Arkh Patol. 1988 ;50(8):13-20.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Anticardiolipin antibodies in systemic sclerosis: immunological and clinical associations.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 8 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information