Department of Medicine, Medical College of Ohio, Toledo.
Four patients are described who experienced an acute episode of eczematous dermatitis of the scrotum where 5-fluorouracil (Efudex) cream had inadvertently been applied in the course of treating warts and keratoses. The reaction was not allergic in origin but resulted from the unique absorptive capabilities of scrotal skin, which permitted entrance and local toxic effects of 5-fluorouracil.