Dopamine Is Differentially Encoded by D2 Receptors in Striatal Subregions

Michel Engeln; Megan E Fox; Mary Kay Lobo

doi:10.1016/j.neuron.2018.04.016

Dopamine Is Differentially Encoded by D2 Receptors in Striatal Subregions

Neuron. 2018 May 2;98(3):459-461. doi: 10.1016/j.neuron.2018.04.016.

Authors

Michel Engeln¹, Megan E Fox¹, Mary Kay Lobo²

Affiliations

¹ Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
² Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: mklobo@som.umaryland.edu.

PMID: 29723497
DOI: 10.1016/j.neuron.2018.04.016

Abstract

Striatal dopamine signaling is differentially regulated along the dorso-ventral axis, but how these differences are encoded by dopamine receptors is unknown. In this issue of Neuron, Marcott et al. (2018) show that dopamine activates D2 receptors in regionally distinct ways and dissect the underlying mechanisms behind striatal D2 heterogeneity.

Keywords: D2 receptors; Parkinson’s disease; addiction; dopamine; dorsal striatum; nucleus accumbens; schizophrenia.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Corpus Striatum
Dopamine*
Neurons
Nucleus Accumbens*
Receptors, Dopamine D2

Substances

Receptors, Dopamine D2
Dopamine

Abstract

Publication types

MeSH terms

Substances

Grants and funding