Hold the Door: Role of the Gut Barrier in Diabetes

Anthony Martin; Suzanne Devkota

doi:10.1016/j.cmet.2018.04.017

Hold the Door: Role of the Gut Barrier in Diabetes

Cell Metab. 2018 May 1;27(5):949-951. doi: 10.1016/j.cmet.2018.04.017.

Authors

Anthony Martin¹, Suzanne Devkota²

Affiliations

¹ Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
² Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: suzanne.devkota@cshs.org.

PMID: 29719231
DOI: 10.1016/j.cmet.2018.04.017

Abstract

While metabolic tissues such as adipose, liver, muscle, and pancreas have been extensively studied in dysmetabolism, the contribution of the gut remains poorly understood. In a recent Science article, Thaiss et al. (2018) unravel mechanisms underlying intestinal permeability observed in obesity and link barrier dysfunction and risk for infection with hyperglycemia.

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MeSH terms

Diabetes Mellitus*
Humans
Hyperglycemia*
Intestines
Obesity
Permeability