Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 1988 Sep 23;241(4873):1632-9.

The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function.

Author information

  • 1Department of Radiation Oncology, Stanford University School of Medicine, CA 94305.

Abstract

The study of human hematopoietic cells and the human immune system is hampered by the lack of a suitable experimental model. Experimental data are presented showing that human fetal liver hematopoietic cells, human fetal thymus, and human fetal lymph node support the differentiation of mature human T cells and B cells after engraftment into mice with genetically determined severe combined immunodeficiency. The resultant SCID-hu mice are found to have a transient wave of human CD4+ and CD8+ T cells and human IgG (immunoglobulin G) in the peripheral circulation. The functional status of the human immune system within this mouse model is not yet known.

PMID:
2971269
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk