Topological Links between Duplex DNA and a Circular DNA Single Strand

Heiko Kuhn; Vadim V Demidov; Maxim D Frank-Kamenetskii

doi:10.1002/(SICI)1521-3773(19990517)38:10<1446::AID-ANIE1446>3.0.CO;2-3

Topological Links between Duplex DNA and a Circular DNA Single Strand

Angew Chem Int Ed Engl. 1999 May 17;38(10):1446-1449. doi: 10.1002/(SICI)1521-3773(19990517)38:10<1446::AID-ANIE1446>3.0.CO;2-3.

Authors

Heiko Kuhn¹, Vadim V Demidov¹, Maxim D Frank-Kamenetskii¹

Affiliation

¹ Center for Advanced Biotechnology, and Department of Biomedical Engineering, Boston University, 36 Cummington Street, Boston, MA 02215 (USA), Fax: (+1) 617-353-8501.

Abstract

DNA nanostructures of building blocks topologically linked at a precise position can be assembled from DNA duplexes and circularized oligonucleotides with the aid of peptide nucleic acids (PNAs). Shown schematically is a linked catenane yielding an earring topological DNA label.

Keywords: Catenanes; DNA structures; Nanostructures; Rotaxanes; Supramolecular chemistry.