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Eur J Epidemiol. 1988 Jun;4(2):256-8.

Immune response to hepatitis B vaccine given at different injection sites and by different routes: a controlled randomized study.

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  • 1Department of Infectious Diseases, S. Anna Hospital, Milan, Italy.


Two-hundred-ninety-nine hospital workers were randomly allocated to receive MSD hepatitis B vaccine in different injection sites and by different routes (intramuscularly by gluteal or deltoid injections or subcutaneously in the arm) or Pasteur vaccine subcutaneously. Highest rates of seroconversion and highest mean anti-HB, titres were found in subjects given MSD vaccine by intramuscular injection into the deltoid muscle.

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