Science. 1988 Jul 29;241(4865):585-9.

cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily.

Sims JE, March CJ, Cosman D, Widmer MB, MacDonald HR, McMahan CJ, Grubin CE, Wignall JM, Jackson JL, Call SM, et al.

Source

Immunex Corporation, Seattle, WA 98101.

Abstract

Interleukin-1 alpha and -1 beta (IL-1 alpha and IL-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis. A direct expression strategy was used to clone the receptor for IL-1 from mouse T cells. The product of the cloned complementary DNA binds both IL-1 alpha and IL-1 beta in a manner indistinguishable from that of the native T cell IL-1 receptor. The extracellular, IL-1 binding portion of the receptor is 319 amino acids in length and is composed of three immunoglobulin-like domains. The cytoplasmic portion of the receptor is 217 amino acids long.

PMID:: 2969618; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

KOMP Repository

Miscellaneous

Mouse Genome Informatics (MGI)

Supplemental Content

Save items

Related citations in PubMed

Cloning the interleukin 1 receptor from human T cells. [Proc Natl Acad Sci U S A. 1989]
Cloning the interleukin 1 receptor from human T cells.
Sims JE, Acres RB, Grubin CE, McMahan CJ, Wignall JM, March CJ, Dower SK. Proc Natl Acad Sci U S A. 1989 Nov; 86(22):8946-50.
Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. [Cell. 1990]
Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily.
Goodwin RG, Friend D, Ziegler SF, Jerzy R, Falk BA, Gimpel S, Cosman D, Dower SK, March CJ, Namen AE. Cell. 1990 Mar 23; 60(6):941-51.
Molecular cloning and expression of the human interleukin 5 receptor. [J Exp Med. 1992]
Molecular cloning and expression of the human interleukin 5 receptor.
Murata Y, Takaki S, Migita M, Kikuchi Y, Tominaga A, Takatsu K. J Exp Med. 1992 Feb 1; 175(2):341-51.
Review [Function, molecular structure and gene expression of IL-8]. [Nihon Rinsho. 1992]
Review [Function, molecular structure and gene expression of IL-8].
Okamoto S, Nomura H, Matsushima K. Nihon Rinsho. 1992 Aug; 50(8):1816-20.
Review Biology of the interleukin-1 receptor. [J Invest Dermatol. 1990]
Review Biology of the interleukin-1 receptor.
Dower SK, Qwarnstrom EE, Page RC, Blanton RA, Kupper TS, Raines E, Ross R, Sims JE. J Invest Dermatol. 1990 Jun; 94(6 Suppl):68S-73S.

See reviews... See all...

Cited by 89 PubMed Central articles

The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation. [Proc Natl Acad Sci U S A. 2012]
The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation.
Chen R, Li M, Zhang Y, Zhou Q, Shu HB. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14128-33. Epub 2012 Aug 16.
Identification of 34 novel proinflammatory proteins in a genome-wide macrophage functional screen. [PLoS One. 2012]
Identification of 34 novel proinflammatory proteins in a genome-wide macrophage functional screen.
Wyllie DH, Søgaard KC, Holland K, Yaobo X, Bregu M, Hill AV, Kiss-Toth E. PLoS One. 2012; 7(7):e42388. Epub 2012 Jul 31.
Trial Watch: Immunostimulatory cytokines. [Oncoimmunology. 2012]
Trial Watch: Immunostimulatory cytokines.
Vacchelli E, Galluzzi L, Eggermont A, Galon J, Tartour E, Zitvogel L, Kroemer G. Oncoimmunology. 2012 Jul 1; 1(4):493-506.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Protein Clusters
Clusters of related proteins from the Protein Clusters database that cite the current articles. Sources of references in Protein Clusters include the associated Gene and Conserved Domain records as well as NCBI added citations.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Domains
Conserved Domain Database (CDD) records that cite the current articles. Citations are from the CDD source database records (PFAM, SMART).
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin sup...
cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily.
Science. 1988 Jul 29 ;241(4865):585-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily.

Source

Abstract

Publication Types, MeSH Terms, Substances, Secondary Source ID

Publication Types

MeSH Terms

Substances

Secondary Source ID

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Miscellaneous

Supplemental Content

Save items

Related citations in PubMed

Cited by 89 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information