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Ann Intern Med. 1988 Jul 15;109(2):101-5.

Antibody to human immunodeficiency virus (HIV) and suboptimal response to hepatitis B vaccination.

Author information

  • 1University of Washington, Seattle.

Abstract

STUDY OBJECTIVE:

To analyze the relation between human immunodeficiency virus (HIV) infection and the antibody response to plasma-derived hepatitis B vaccine.

DESIGN:

Open-label longitudinal cohort study; blinded laboratory studies.

SETTING:

University-affiliated municipal hospital. Patients: Homosexually active men with negative assays for hepatitis B surface antigen (HBsAg), hepatitis B core antigen, and antibody to HBsAg; recruited in a sexually transmitted disease clinic or referred from community practitioners.

INTERVENTIONS:

Immunization with 20 micrograms of plasma-derived hepatitis B virus vaccine intramuscularly, repeated after 1 and 6 months; standardized evaluation at entry and at 1, 2, 6, and 7 months.

MEASUREMENTS AND MAIN RESULTS:

Low antibody response or nonresponse to vaccination occurred in 7 of 16 HIV-seropositive patients, compared with 6 of 68 HIV-seronegative patients (P = 0.002). Median levels of antibody to HBsAg 7 months after the first vaccine dose were 205.3 sample ratio units for HIV-seronegative patients and 15.5 sample ratio units for HIV-seropositive patients. By multivariate analysis, vaccine response was associated with HIV antibody status and not with cytomegalovirus infection, lymphocyte subset results, or impaired cutaneous delayed hypersensitivity.

CONCLUSIONS:

Infection with HIV is associated with suboptimal antibody response to plasma-derived hepatitis B virus vaccine. Determination of antibody levels after vaccination in HIV-seropositive patients may be warranted.

PMID:
2968064
[PubMed - indexed for MEDLINE]
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