The role of Next-Generation Sequencing in tumoral radiosensitivity prediction

Jean-Emmanuel Bibault; Ingeborg Tinhofer

doi:10.1016/j.ctro.2017.03.002

The role of Next-Generation Sequencing in tumoral radiosensitivity prediction

Clin Transl Radiat Oncol. 2017 Apr 9:3:16-20. doi: 10.1016/j.ctro.2017.03.002. eCollection 2017 Apr.

Authors

Jean-Emmanuel Bibault^{1

2}, Ingeborg Tinhofer³

Affiliations

¹ Radiation Oncology Department, Georges Pompidou European Hospital, Assistance Publique - Hôpitaux de Paris, Paris Descartes University, Paris Sorbonne Cité, Paris, France.
² INSERM UMR 1138 Team 22: Information Sciences to Support Personalized Medicine, Paris Descartes University, Sorbonne Paris Cité, Paris, France.
³ Department of Radiooncology and Radiotherapy, Charité University Hospital Berlin, Berlin, Germany.

Abstract

Technological advances have led to more precise radiation delivery, which has resulted in significant clinical gains. A better understanding of tumoral radiosensitivity is still needed to develop strategies and further personalize radiation treatments. Next-Generation Sequencing (NGS) and system biology have significantly transformed the field of oncology in the last two decades, but have only a few clinical applications in radiation oncology. This review describes the technical aspects and evolutions of NGS and discusses the latest clinical applications of genomics to predict tumoral radiosensitivity.

Keywords: Genomics; Next-Generation Sequencing; Radiation oncology; Radiosensitivity.

Publication types

Review