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Biochem Med Metab Biol. 1987 Dec;38(3):272-7.

Effect of Withania somnifera on glycosaminoglycan synthesis in carrageenin-induced air pouch granuloma.

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  • 1Department of Siddha Medicine, Faculty of Sciences, Tamil University, India.

Abstract

The effect of W. somnifera on glycosaminoglycan synthesis in the granulation tissue of carrageenin-induced air pouch granuloma was studied. W. somnifera was shown to exert significant inhibitory effect on incorporation of 35S into the granulation tissue. The uncoupling effect on oxidative phosphorylation (ADP/O ratio reduction) was also observed in the mitochondria of granulation tissue. Further, Mg2+ dependent ATPase activity was found to be influenced by W. somnifera. W. somnifera also reduced the succinate dehydrogenase enzyme activity in the mitochondria of granulation tissue.

PMID:
2963652
[PubMed - indexed for MEDLINE]
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