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FEBS Lett. 1988 Jan 25;227(2):131-5.

Purification and characterization of a lipocortin-like 33 kDa protein from guinea pig neutrophils.

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  • 1Department of Medical Biology, Kochi Medical School, Japan.

Abstract

A lipocortin-like, phospholipase A2 inhibitory 33 kDa protein was purified from guinea pig neutrophils. From amino acid composition and sequence data, this protein was found to have a high degree of homology to human lipocortin I. This protein inhibited porcine pancreatic phospholipase A2 activity in the presence of [3H]oleic acid-labeled Escherichia coli membranes as substrate. Maximal inhibition amounted to 65% whereas 50% inhibition occurred at 83.5 nM. This protein showed F-actin-binding ability in a Ca2+-dependent manner.

PMID:
2962884
[PubMed - indexed for MEDLINE]
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