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The gene for protein S maps near the centromere of human chromosome 3.
Integrated Genetics, Inc, Framingham, MA 01701.
Two different mapping approaches were used to determine the human chromosomal location of the gene for protein S. A human protein S cDNA was used as a hybridization probe to analyze a panel of somatic cell hybrids containing different human chromosomes. Cosegregation of protein S-specific DNA restriction fragments with human chromosome 3 was observed. Three cell hybrids containing only a portion of chromosome 3 were analyzed in order to further localize protein S. Based on the somatic cell hybrid analysis, protein S is assigned to a region of chromosome 3 that contains a small part of the long arm and short arm of the chromosome including the centromere (3p21----3q21). In situ hybridization of the protein S cDNA probe to human metaphase chromosomes permitted a precise localization of protein S to the region of chromosome 3 immediately surrounding the centromere (3p11.1----3q11.2). Protein S is the first protein involved in blood coagulation that has been mapped to human chromosome 3.
PMID: 2961379 [PubMed - indexed for MEDLINE]
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Cited by 4 PubMed Central articles
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Autosomal dominant avascular necrosis of femoral head in two Taiwanese pedigrees and linkage to chromosome 12q13.
Chen WM, Liu YF, Lin MW, Chen IC, Lin PY, Lin GL, Jou YS, Lin YT, Fann CS, Wu JY, et al.
Am J Hum Genet. 2004 Aug; 75(2):310-7. Epub 2004 Jun 3.
[Am J Hum Genet. 2004]
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Vitamin K-dependent protein S in Leydig cells of human testis.
Malm J, He XH, Bjartell A, Shen L, Abrahamsson PA, Dahlbäck B.
Biochem J. 1994 Sep 15; 302 ( Pt 3):845-50.
[Biochem J. 1994]
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A CCA/CCG neutral dimorphism in the codon for Pro 626 of the human protein S gene PS alpha (PROS1).
Diepstraten CM, van Amstel JK, Reitsma PH, Bertina RM.
Nucleic Acids Res. 1991 Sep 25; 19(18):5091.
[Nucleic Acids Res. 1991]
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