Perimenstrual asthma: Report of a case with therapeutic intervention of oral prednisone

J Asthma. 2018 Dec;55(12):1328-1330. doi: 10.1080/02770903.2017.1418886. Epub 2018 Mar 27.

Abstract

Introduction: Many asthmatic women of childbearing age experience cyclical aggravation of asthmatic symptoms during the perimenstrual period, or perimenstrual asthma (PMA). PMA is considered to be a difficult-to-treat asthma phenotype; conventional asthma therapies are not always effective against PMA.

Case study: We report a case of a 27-year-old female with PMA who had received standard asthma treatment since 2013.

Result: The patient showed a dramatic response to therapeutic intervention of oral prednisone, taken for 7 days prior to menstruation each month, in a dose-dependent manner.

Conclusion: Premenstrual treatment with oral prednisone may be a successful new direction for the treatment of PMA, a troublesome type of asthma.

Keywords: Asthma; oral prednisone; perimenstrual asthma; therapeutic intervention.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Asthmatic Agents / administration & dosage
  • Anti-Asthmatic Agents / therapeutic use*
  • Asthma / drug therapy*
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Menstruation / physiology*
  • Phenotype
  • Prednisone / administration & dosage
  • Prednisone / therapeutic use*

Substances

  • Anti-Asthmatic Agents
  • Prednisone