Self-reported adverse reactions associated with mycoprotein (Quorn-brand) containing foods

Ann Allergy Asthma Immunol. 2018 Jun;120(6):626-630. doi: 10.1016/j.anai.2018.03.020. Epub 2018 Mar 19.

Abstract

Background: Mycoprotein, which is produced by a mold and is the basis of Quorn-brand meat substitutes, is a novel cause of allergic and gastrointestinal reactions, but little information has been available on its associated symptomatology.

Objective: To describe the nature and frequency of adverse reactions to mycoprotein.

Methods: Self-reports of adverse reactions to mycoprotein were collected via a Web-based questionnaire (www.quorncomplaints.org) and then analyzed.

Results: Analysis of 1,752 adverse reactions found that Quorn products caused allergic and gastrointestinal symptoms, with some people experiencing both. Allergic reactions, including urticaria and anaphylaxis, occurred within 4 hours of consumption in 312 people. Of those reactions, 45.8%, 1 fatal, began within 1 hour of exposure. Of those 312 individuals, 188 (60.3%) reported repeated reactions after repeated consumption of Quorn, and 2 people experienced 8 reactions (13 people did not say whether they experienced more than 1 reaction). Quorn foods caused gastrointestinal symptoms, including emesis and diarrhea, within 8 hours of consumption in 1,692 people. Of the gastrointestinal symptoms, 66.6% occurred 46 to 180 minutes after consumption of the products. Symptoms ranged from mild nausea to emesis severe enough to warrant medical attention.

Conclusion: Mycoprotein may be causing numerous and sometimes life-threatening allergic and gastrointestinal reactions. The acceptance in the food supply of this nonessential ingredient deserves reconsideration.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anaphylaxis / chemically induced
  • Anaphylaxis / diagnosis*
  • Anaphylaxis / immunology
  • Anaphylaxis / physiopathology
  • Child
  • Child, Preschool
  • Diarrhea / chemically induced
  • Diarrhea / diagnosis
  • Diarrhea / immunology
  • Diarrhea / physiopathology
  • Dietary Exposure / adverse effects*
  • Female
  • Food / toxicity
  • Food Hypersensitivity / diagnosis*
  • Food Hypersensitivity / etiology
  • Food Hypersensitivity / immunology
  • Food Hypersensitivity / physiopathology
  • Fungal Proteins / adverse effects*
  • Fusarium / chemistry
  • Fusarium / immunology
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Nausea / chemically induced
  • Nausea / diagnosis
  • Nausea / immunology
  • Nausea / physiopathology
  • Self Report
  • Surveys and Questionnaires
  • Urticaria / chemically induced
  • Urticaria / diagnosis*
  • Urticaria / immunology
  • Urticaria / physiopathology
  • Vomiting / chemically induced
  • Vomiting / diagnosis
  • Vomiting / immunology
  • Vomiting / physiopathology

Substances

  • Fungal Proteins