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    FEBS Lett. 1987 Aug 10;220(1):129-35.

    A cDNA coding for human sex hormone binding globulin. Homology to vitamin K-dependent protein S.

    Gershagen S, Fernlund P, Lundwall A.

    Affinity purified antibodies to human sex hormone binding globulin (SHBG) were used in screening a human liver cDNA library, constructed in the expression vector lambda gt11. One clone, identified as producing recombinant SHBG, carried a cDNA insert of 1.1 kb. The nucleotide sequence of the insert had an open reading frame coding for 356 amino acid residues. The coding sequence was followed by a short 3'-region of 19 non-translated nucleotides and a poly(A) tail. Confirmation that the cDNA clone represented human SHBG was obtained by the finding of a complete agreement in amino acid sequence with several peptide fragments generated from purified SHBG by proteolytic cleavage. The primary structure of SHBG shows a considerable homology to that of protein S, a vitamin K-dependent protein with functions in the coagulation system.

    PMID: 2956126 [PubMed - indexed for MEDLINE]

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