Clinical and functional impact of recurrent S1PR1 mutations in mantle cell lymphoma

Blood Adv. 2018 Mar 27;2(6):621-625. doi: 10.1182/bloodadvances.2017014860.

Abstract

  1. S1PR1 mutations are present in 7.8% of patients with MCL and are significantly more frequent at relapse.

  2. S1PR1 mutations reduce expression of the S1PR1 receptor, which mediates migration towards the tissue-to-blood egress factor S1P in MCL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Exons
  • Gene Expression
  • Genetic Association Studies*
  • Genetic Predisposition to Disease*
  • Humans
  • Immunohistochemistry
  • Lymphoma, Mantle-Cell / diagnosis*
  • Lymphoma, Mantle-Cell / genetics*
  • Mutation*
  • Prognosis
  • Receptors, Lysosphingolipid / genetics*
  • Recurrence
  • Sphingosine-1-Phosphate Receptors

Substances

  • Receptors, Lysosphingolipid
  • S1PR1 protein, human
  • Sphingosine-1-Phosphate Receptors