POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M protein and Skin changes) syndrome in a patient with solitary osteolytic plasmacytoma has been reported in this communication. He presented with a demyelinating polyneuropathy, lytic lesion in the left femur and hypogonadism. Serum protein electrophoresis, urine Bence-Jones protein and multiple bone marrow aspirations were negative for the presence of a myeloma. A biopsy from the lytic lesion confirmed the diagnosis of plasmacytoma.