Granulomonocytic progenitors are key target cells of azacytidine in higher risk myelodysplastic syndromes and acute myeloid leukemia

Ashfaq Ali; Justine Penneroux; Reinaldo Dal Bello Jr; Aline Massé; Samuel Quentin; Ashwin Unnikrishnan; Lucie Hernandez; Emmanuel Raffoux; Raouf Ben Abdelali; Aline Renneville; Claude Preudhomme; John Pimanda; Hervé Dombret; Jean Soulier; Pierre Fenaux; Emmanuelle Clappier; Lionel Adès; Alexandre Puissant; Raphael Itzykson

doi:10.1038/s41375-018-0076-2

Granulomonocytic progenitors are key target cells of azacytidine in higher risk myelodysplastic syndromes and acute myeloid leukemia

Leukemia. 2018 Aug;32(8):1856-1860. doi: 10.1038/s41375-018-0076-2. Epub 2018 Feb 26.

Authors

Ashfaq Ali^{1

2}, Justine Penneroux^{1

2}, Reinaldo Dal Bello Jr^{1

2

3

4}, Aline Massé^{1

2}, Samuel Quentin^{1

2

5}, Ashwin Unnikrishnan⁶, Lucie Hernandez^{1

2

5}, Emmanuel Raffoux³, Raouf Ben Abdelali^{1

2

5}, Aline Renneville⁷, Claude Preudhomme⁷, John Pimanda⁶, Hervé Dombret^{2

3}, Jean Soulier^{1

2

5}, Pierre Fenaux^{1

2

3}, Emmanuelle Clappier^{1

2

5}, Lionel Adès^{1

2

3}, Alexandre Puissant^{1

2}, Raphael Itzykson^{8

9

10}

Affiliations

¹ INSERM/CNRS UMR 944/7212, Paris, France.
² Institut Universitaire d'Hématologie, Paris Cancer Research Institute (PACRI), Université Paris Diderot, Paris, France.
³ Hematology Department, Hopital Saint Louis, Assistance Publique - Hopitaux de Paris, University Paris Diderot, Paris, France.
⁴ Hematology Department, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
⁵ Laboratory of Hematology, Hopital Saint Louis, Assistance Publique - Hopitaux de Paris, University Paris Diderot, Paris, France.
⁶ Lowy Cancer Research Centre, Prince of Wales Clinical School, UNSW Sydney, Sydney, NSW 2025, Australia.
⁷ Hematology Laboratory, Biology and Pathology Center, CHRU of Lille, Lille, France.
⁸ INSERM/CNRS UMR 944/7212, Paris, France. raphael.itzykson@aphp.fr.
⁹ Institut Universitaire d'Hématologie, Paris Cancer Research Institute (PACRI), Université Paris Diderot, Paris, France. raphael.itzykson@aphp.fr.
¹⁰ Hematology Department, Hopital Saint Louis, Assistance Publique - Hopitaux de Paris, University Paris Diderot, Paris, France. raphael.itzykson@aphp.fr.

PMID: 29535430
DOI: 10.1038/s41375-018-0076-2

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antimetabolites, Antineoplastic / pharmacology
Azacitidine / pharmacology*
Biomarkers, Tumor / genetics
Gene Expression Regulation, Neoplastic / drug effects
Granulocytes / drug effects
Granulocytes / metabolism
Granulocytes / pathology*
Hematopoietic Stem Cells / drug effects
Hematopoietic Stem Cells / metabolism
Hematopoietic Stem Cells / pathology*
High-Throughput Nucleotide Sequencing / methods
Humans
Leukemia, Myeloid, Acute / drug therapy*
Leukemia, Myeloid, Acute / pathology
Multipotent Stem Cells / drug effects
Multipotent Stem Cells / metabolism
Multipotent Stem Cells / pathology*
Myelodysplastic Syndromes / drug therapy*
Myelodysplastic Syndromes / pathology
Pilot Projects
Prognosis
Prospective Studies

Substances

Antimetabolites, Antineoplastic
Biomarkers, Tumor
Azacitidine