Severe multiple sclerosis reactivation after gonadotropin treatment

Mult Scler Relat Disord. 2018 May:22:38-40. doi: 10.1016/j.msard.2018.02.031. Epub 2018 Mar 6.

Abstract

Several reports indicate increased disease activity in patients with multiple sclerosis (MS) undergoing assisted reproductive techniques (ART), in the form of gonadtopin releasing hormone (GnRH) agonists. Other forms of ART treatments, like gonadotropin-treatment, have therefore been considered a safer option for MS-patients. We present a patient who despite being completely clinically and radiologically stable for eight years during disease modifying therapy experienced a nearly fulminant disease course almost immediately after starting gonadotropin-treatment, indicating that this form of follicle stimulating treatment could also be a major risk factor for MS disease activity.

Keywords: Autoimmune diseases; Multiple sclerosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain / diagnostic imaging
  • Female
  • Gonadotropins / adverse effects*
  • Gonadotropins / therapeutic use
  • Humans
  • Multiple Sclerosis, Relapsing-Remitting / diagnostic imaging
  • Multiple Sclerosis, Relapsing-Remitting / drug therapy
  • Multiple Sclerosis, Relapsing-Remitting / physiopathology*
  • Reproductive Techniques, Assisted / adverse effects*
  • Spinal Cord / diagnostic imaging

Substances

  • Gonadotropins