Screening recipients of increased risk donor organs: A multicenter retrospective study

Transpl Infect Dis. 2018 Jun;20(3):e12862. doi: 10.1111/tid.12862. Epub 2018 Mar 26.

Abstract

Organ Procurement & Transplantation Network policy requires post-transplant screening of recipients of organs from donors at increased risk for transmission of HIV, hepatitis B virus, and hepatitis C virus. Available data suggest that follow-up testing of recipients is not routinely conducted. Data on increased risk donors and recipients of their organs from 2008 to 2012 were retrospectively collected from 6 transplant centers after IRB approval. Descriptive statistics were performed. About 363 (60%) recipients were screened for transmission of HIV, HBV, and/or HCV at some time point; 257 (70.8%) within 90 days of transplant. The type of test used to screen for infection was variable with many recipients (25%-43%) screened with serology alone. Our results reveal that post-transplant screening for HIV, HBV, and HCV in recipients of increased risk donor organs did not universally occur and testing methods were variable.

Keywords: HIV; PHS increased risk donors; hepatitis B; hepatitis C; organ recipients; screening.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Child, Preschool
  • Female
  • HIV Infections / prevention & control
  • HIV Infections / transmission*
  • Hepatitis B / prevention & control
  • Hepatitis B / transmission*
  • Hepatitis C / prevention & control
  • Hepatitis C / transmission*
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Mass Screening*
  • Middle Aged
  • Organ Transplantation / adverse effects
  • Organ Transplantation / statistics & numerical data
  • Retrospective Studies
  • Risk Factors
  • Tissue Donors*
  • Tissue and Organ Procurement
  • Transplant Recipients / statistics & numerical data*
  • Young Adult