[Vaginal mesh operations in the urogynecological practice after the FDA warnings. Use or not to use mesh?]

Orv Hetil. 2018 Mar;159(10):397-404. doi: 10.1556/650.2018.30963.
[Article in Hungarian]

Abstract

Introduction: The prevalence of pelvic organ prolapse (POP) with aging is escalating alarmingly, and now becoming a growing epidemic among the elderly. Synthetic transvaginal mesh (TVM) has been employed with increasing popularity in the treatment of POP until the end of the last decade. After the U.S. Drug and Food Administration (FDA) warnings in the years 2008 and 2011, the number of vaginal mesh operations has decreased dramatically.

Aim: The aim of the study was to evaluate and compare the anti-POP effectivity, the anti-stress incontinence (anti-SUI) efficacy, and the late (36 months) post-operative complications of the anterior vaginoplasty and the TVM operations.

Method: We analysed the clinical data from 120 patients with stage II-III anterior prolapse and concomitant SUI who had undergone surgery at a tertiary referral centre in Hungary between January 2013 and January 2014. Sixty patients underwent Kelly-Stoeckel vaginoplasty and the other 60 cases had TVM operation. The surgical complications were classified using the Clavien-Dindo (CD) classification system.

Results: The anti-POP (91.6% vs. 63.3%; p<0.001) and the anti-SUI efficacy (90% vs. 55%, p<0.001) were significantly higher in the TVM group than in the vaginoplasty group, while the overall extrusion rate was found 8.3% after a 3-year follow-up. The Clavien-Dindo score (CD) proved that the early post-operative complication profile was similar among the TVM patients as compared to the vaginoplasty group (p = 0.405).

Conclusion: Vaginal mesh surgery represents an effective procedure for prolapse and concomitant SUI with a decreased risk of short- and long-term complications. Orv Hetil. 2018; 159(10): 397-404.

Keywords: Clavien–Dindo classification; Clavien–Dindo-klasszifikáció; SUI with POP–Q II–III; SUI és POP–Q II–III; anterior vaginoplasty; complications; komplikációk; mellső hüvelyplastica; transvaginal mesh; transvaginalis hálóműtét.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Female
  • Gynecologic Surgical Procedures / statistics & numerical data
  • Humans
  • Hungary
  • Middle Aged
  • Minimally Invasive Surgical Procedures / statistics & numerical data
  • Patient Satisfaction
  • Postoperative Complications / epidemiology*
  • Surgical Mesh / adverse effects
  • Surgical Mesh / statistics & numerical data*
  • United States
  • United States Food and Drug Administration
  • Urinary Incontinence, Stress / epidemiology
  • Urinary Incontinence, Stress / surgery*
  • Uterine Prolapse / epidemiology
  • Uterine Prolapse / surgery*