The integrated stress response system in cardiovascular disease

Drug Discov Today. 2018 Apr;23(4):920-929. doi: 10.1016/j.drudis.2018.02.008. Epub 2018 Feb 27.

Abstract

The integrated stress response system represents an ancillary, extremely conserved signalling pathway present in virtually all eukaryotic cells, which plays an important part in the pathophysiology of several disorders such as cancer and neurodegeneration. However, its role in the cardiovascular system remains largely elusive. Hence, this review aims to acknowledge recent findings regarding the action of the eIF2α kinases in the cardiovascular system and their role in the pathophysiology of related disorders.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / metabolism*
  • Cardiovascular Diseases / pathology*
  • Humans
  • Signal Transduction / physiology
  • Stress, Physiological / physiology*
  • eIF-2 Kinase / metabolism

Substances

  • eIF-2 Kinase