Assessing the potential impact of limited public health resources on the spread and control of typhoid

J Math Biol. 2018 Sep;77(3):647-670. doi: 10.1007/s00285-018-1219-9. Epub 2018 Feb 27.

Abstract

Typhoid fever is a systemic infection caused by Salmonella Typhi and occurs predominantly in association with poor sanitation and lack of clean drinking water. Despite recent progress in water and sanitation coverage, the disease remains a substantial public health problem in many developing countries. A mathematical model for the spread of typhoid has been formulated using non linear ordinary differential equations. The model includes a special treatment function to assess the effects of limited treatment resources on the spread of typhoid. It is shown that the model has multiple equilibria and using the center manifold theory, the model exhibits the phenomenon of backward bifurcation whose implications are discussed. The results suggest the need for comprehensive and accessible treatment facilities to curtail typhoid infection.

Keywords: Reproduction number; Treatment; Treatment function; Typhoid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Basic Reproduction Number / statistics & numerical data
  • Computer Simulation
  • Developing Countries
  • Endemic Diseases / prevention & control
  • Endemic Diseases / statistics & numerical data
  • Health Resources
  • Humans
  • Mathematical Concepts
  • Models, Biological*
  • Nonlinear Dynamics
  • Public Health
  • Typhoid Fever / prevention & control*
  • Typhoid Fever / therapy
  • Typhoid Fever / transmission*