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Molecular cloning of cDNA coding for human PGP 9.5 protein. A novel cytoplasmic marker for neurones and neuroendocrine cells.
The co-ordinate sequencing of the human neuronal and neuroendocrine marker protein PGP 9.5 and its cDNA is described. The cDNA encodes the complete protein (212 amino acids), and the 340 nucleotide 3'-noncoding region including the polyadenylation signal, indicating an mRNA slightly larger than 1 kb in size. Protein sequencing of 50% of PGP 9.5 confirms the deduced protein sequence.
PMID: 2947814 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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PGP9.5 as a candidate tumor marker for non-small-cell lung cancer.
Hibi K, Westra WH, Borges M, Goodman S, Sidransky D, Jen J.
Am J Pathol. 1999 Sep; 155(3):711-5.
[Am J Pathol. 1999]
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Effect of three animal models of inflammation on nerve fibres in the synovium.
Mapp PI, Walsh DA, Garrett NE, Kidd BL, Cruwys SC, Polak JM, Blake DR.
Ann Rheum Dis. 1994 Apr; 53(4):240-6.
[Ann Rheum Dis. 1994]
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The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase.
Day IN, Hinks LJ, Thompson RJ.
Biochem J. 1990 Jun 1; 268(2):521-4.
[Biochem J. 1990]