Imaging Nano-Bio Interactions in the Kidney: Toward a Better Understanding of Nanoparticle Clearance

Junqing Wang; Gang Liu

doi:10.1002/anie.201711705

Imaging Nano-Bio Interactions in the Kidney: Toward a Better Understanding of Nanoparticle Clearance

Angew Chem Int Ed Engl. 2018 Mar 12;57(12):3008-3010. doi: 10.1002/anie.201711705. Epub 2018 Feb 16.

Authors

Junqing Wang¹, Gang Liu¹

Affiliation

¹ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, Fujian, 361102, China.

PMID: 29450950
DOI: 10.1002/anie.201711705

Abstract

All clear! Highlighted is work aimed at a better understanding of nano-bio interactions for rational design of renal-clearable nanoparticles in diseased kidneys. Renal clearance of ultra-small gold nanoparticles (AuNPs) is not only dependent upon the Choi criteria but is also affected by the microphysiological structure of the glomerular barrier and the pathophysiological changes in the nephron.

Keywords: gold; imaging agents; kidney; nanomedicine; nanoparticles.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Gold / chemistry*
Gold / pharmacokinetics*
Humans
Kidney / chemistry
Kidney / metabolism*
Metal Nanoparticles / chemistry*
Nanomedicine*
Particle Size
Surface Properties

Substances

Gold