Action and toxicity of cyclosporine

Annu Rev Med. 1986:37:215-24. doi: 10.1146/annurev.me.37.020186.001243.

Abstract

Cyclosporine is a potent new immunosuppressive agent that has proven particularly useful in organ transplantation. The unique action of the drug on T-cell immunity without myelosuppression is summarized. Cyclosporine pharmacology and adverse reactions, particularly nephrotoxicity, are reviewed in this paper.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury / chemically induced
  • Blood Coagulation Disorders / chemically induced
  • Cyclosporins / adverse effects
  • Cyclosporins / blood
  • Cyclosporins / metabolism
  • Cyclosporins / pharmacology*
  • Gingival Hyperplasia / chemically induced
  • Graft Rejection
  • Heart Transplantation
  • Hirsutism / chemically induced
  • Humans
  • Kidney / drug effects
  • Kidney Diseases / chemically induced
  • Kidney Transplantation
  • Liver / drug effects
  • Lymphoma / chemically induced
  • Nervous System / drug effects
  • T-Lymphocytes / drug effects
  • T-Lymphocytes, Helper-Inducer / drug effects
  • T-Lymphocytes, Regulatory / drug effects

Substances

  • Cyclosporins