Abstract
Cyclosporine is a potent new immunosuppressive agent that has proven particularly useful in organ transplantation. The unique action of the drug on T-cell immunity without myelosuppression is summarized. Cyclosporine pharmacology and adverse reactions, particularly nephrotoxicity, are reviewed in this paper.
MeSH terms
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Acute Kidney Injury / chemically induced
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Blood Coagulation Disorders / chemically induced
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Cyclosporins / adverse effects
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Cyclosporins / blood
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Cyclosporins / metabolism
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Cyclosporins / pharmacology*
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Gingival Hyperplasia / chemically induced
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Graft Rejection
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Heart Transplantation
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Hirsutism / chemically induced
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Humans
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Kidney / drug effects
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Kidney Diseases / chemically induced
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Kidney Transplantation
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Liver / drug effects
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Lymphoma / chemically induced
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Nervous System / drug effects
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T-Lymphocytes / drug effects
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T-Lymphocytes, Helper-Inducer / drug effects
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T-Lymphocytes, Regulatory / drug effects