HDAC5 Regulates the Formation of Drug Memories

Alexander C W Smith; Paul J Kenny

doi:10.1016/j.molmed.2017.12.011

HDAC5 Regulates the Formation of Drug Memories

Trends Mol Med. 2018 Feb;24(2):106-108. doi: 10.1016/j.molmed.2017.12.011. Epub 2018 Jan 25.

Authors

Alexander C W Smith¹, Paul J Kenny²

Affiliations

¹ Department of Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029-6574, USA.
² Department of Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029-6574, USA. Electronic address: paul.kenny@mssm.edu.

PMID: 29396145
DOI: 10.1016/j.molmed.2017.12.011

Abstract

Cocaine-associated environmental cues can precipitate craving and relapse in addicted individuals even after years of abstinence, but the molecular mechanisms by which maladaptive drug memories are generated remain unclear. New findings suggest that histone deacetylase 5 (HDAC5) plays a key role in this process.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Cocaine*
Histone Deacetylases*
Humans
Memory

Substances

HDAC5 protein, human
Histone Deacetylases
Cocaine

Abstract

Publication types

MeSH terms

Substances

Grants and funding