Bad germs are trapped

Liman Zhang; Hao Wu

doi:10.1038/cr.2018.5

Bad germs are trapped

Cell Res. 2018 Feb;28(2):141-142. doi: 10.1038/cr.2018.5. Epub 2018 Jan 9.

Authors

Liman Zhang¹, Hao Wu¹

Affiliation

¹ Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.

Abstract

Activation of the NAIP/NLRC4 inflammasomes initiates inflammatory responses against bacterial invasion. Two recent reports described the cryo-EM structure of the flagellin/NAIP5 complex, providing important insights into the mechanism of bacterial sensing by innate immunity.

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MeSH terms

Apoptosis Regulatory Proteins
Calcium-Binding Proteins
Flagellin*
Immune Evasion
Immunity, Innate
Inflammasomes
Neuronal Apoptosis-Inhibitory Protein*

Substances

Apoptosis Regulatory Proteins
Calcium-Binding Proteins
Inflammasomes
Neuronal Apoptosis-Inhibitory Protein
Flagellin