Rattle-type Au@Cu2-xS hollow mesoporous nanocrystals with enhanced photothermal efficiency for intracellular oncogenic microRNA detection and chemo-photothermal therapy

Yu Cao; Shuzhou Li; Chao Chen; Dongdong Wang; Tingting Wu; Haifeng Dong; Xueji Zhang

doi:10.1016/j.biomaterials.2017.12.009

Rattle-type Au@Cu_2-xS hollow mesoporous nanocrystals with enhanced photothermal efficiency for intracellular oncogenic microRNA detection and chemo-photothermal therapy

Biomaterials. 2018 Mar:158:23-33. doi: 10.1016/j.biomaterials.2017.12.009. Epub 2017 Dec 13.

Authors

Yu Cao¹, Shuzhou Li², Chao Chen², Dongdong Wang¹, Tingting Wu¹, Haifeng Dong³, Xueji Zhang⁴

Affiliations

¹ Research Center for Bioengineering and Sensing Technology, Beijing Key Laboratory for Bioengineering and Sensing Technology, School of Chemistry & Biological Engineering University of Science & Technology Beijing, Beijing 100083, PR China.
² School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.
³ Research Center for Bioengineering and Sensing Technology, Beijing Key Laboratory for Bioengineering and Sensing Technology, School of Chemistry & Biological Engineering University of Science & Technology Beijing, Beijing 100083, PR China. Electronic address: hfdong@ustb.edu.cn.
⁴ Research Center for Bioengineering and Sensing Technology, Beijing Key Laboratory for Bioengineering and Sensing Technology, School of Chemistry & Biological Engineering University of Science & Technology Beijing, Beijing 100083, PR China. Electronic address: zhangxueji@ustb.edu.cn.

PMID: 29274527
DOI: 10.1016/j.biomaterials.2017.12.009

Abstract

The coupling of the localized surface plasma resonance (LSPR) between noble metals of Au, Ag and Cu and semiconductors of Cu_2-xE (E = S, Se, Te) opens new regime to design photothermal (PT) agents with enhanced PT conversion efficiency. However, it is rarely explored on fabricating of engineered dual plasmonic hybrid nanosystem for combinatory therapeutic-diagnostic applications. Herein, rattle-type Au@Cu_2-xS hollow mesoporous nanoparitcles with advanced PT conversion efficiency are designed for cellular vehicles and chemo-photothermal synergistic therapy platform. The LSPR coupling between the Au core and Cu_2-xS shell are investigated experimentally and theoretically to generate a PT conversion efficiency high to 35.2% and enhanced by 11.3% than that of Cu_2-xS. By conjugating microRNA (miRNA) gene probe on the surface, it can realize the intracellular oncogenic miRNA detection. After loading of anticancer drug doxorubicin into the cavity of the Au@Cu_2-xS, the antitumor therapy efficacy is greatly enhanced in vitro and in vivo due to the NIR photoactivation chemo- and photothermal synergistic therapy. The rattle-type metal-semiconductor hollow mesoporous nanostructure with efficient LSPR coupling and high cargo loading capability will be beneficial to future design of LSPR-based photothermal agents for a broad range of biomedical application.

Keywords: Chemo-photothermal therapy; Localized surface plasma resonance coupling; MicroRNA detection; Rattle-type Au@Cu(2−x)S; Theranostic platform.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Combined Modality Therapy
Doxorubicin / pharmacology
Drug Carriers* / chemistry
Humans
MCF-7 Cells
MicroRNAs* / analysis
Nanoparticles* / chemistry
Neoplasms / genetics
Neoplasms / therapy
Phototherapy* / methods
Surface Plasmon Resonance
Theranostic Nanomedicine

Substances

Antineoplastic Agents
Drug Carriers
MicroRNAs
Doxorubicin