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    Mutat Res. 1989 Mar;225(3):91-4.

    Formation of 8-hydroxydeoxyguanosine in DNA treated with fecapentaene-12 and -14.

    Shioya M, Wakabayashi K, Yamashita K, Nagao M, Sugimura T.

    Source

    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan.

    Abstract

    Fecapentaene-12 and -14, direct-acting mutagens in human feces, were found to hydroxylate the C-8 position of guanine residues in DNA in vitro. Fecapentaene-12 or -14 was incubated with 0.5 mg of calf thymus DNA in 1 ml of reaction mixture at pH 7.4 for 2 h at 37 degrees C in the dark, and then 8-hydroxydeoxyguanosine (8-OH-dG) was analyzed. In these conditions 8-OH-dG was formed dose-dependently at levels of 1.1-4.6 residues/10(4) dG with concentrations of 0.5-3.0 mM of fecapentaene-12. Similar results were obtained with fecapentaene-14. The amount of 8-OH-dG in untreated DNA was 0.2-0.3 residue/10(4) dG.

    PMID:
    2927433
    [PubMed - indexed for MEDLINE]

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