Feeling Exhausted? Tuning Irf4 Energizes Dysfunctional T Cells

Vijaykumar Chennupati; Werner Held

doi:10.1016/j.immuni.2017.11.028

Feeling Exhausted? Tuning Irf4 Energizes Dysfunctional T Cells

Immunity. 2017 Dec 19;47(6):1009-1011. doi: 10.1016/j.immuni.2017.11.028.

Authors

Vijaykumar Chennupati¹, Werner Held²

Affiliations

¹ Department of Oncology, University of Lausanne, 1066 Epalinges, Switzerland.
² Department of Oncology, University of Lausanne, 1066 Epalinges, Switzerland. Electronic address: werner.held@unil.ch.

PMID: 29262341
DOI: 10.1016/j.immuni.2017.11.028

Abstract

The regulatory mechanisms governing T cell exhaustion remain incompletely understood. Man et al. (2017) and Wu et al. (2017) report that the T cell receptor responsive transcription factor Irf4 promotes T cell exhaustion in chronic viral infection but dampens exhaustion in response to tissue allografts.

Publication types

Comment

MeSH terms

CD8-Positive T-Lymphocytes*
Gene Expression Regulation
Humans
Male
Receptors, Antigen, T-Cell*

Substances

Receptors, Antigen, T-Cell