Ann Neurol. 1979 Jul;6(1):37-9.

Biogenic amine metabolism in Tourette syndrome.

Butler IJ, Koslow SH, Seifert WE Jr, Caprioli RM, Singer HS.

Abstract

Biogenic amine metabolism in the central nervous system of 9 children with Tourette syndrome was evaluated by quantitation of their metabolites in cerebrospinal fluid by a gas chromatographic/mass spectrometric method. Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) were measured in CSF before and after oral administration of probenecid. Dopamine metabolism appeared defective, as both baseline and accumulated levels of HVA after probenecid were decreased. Serotonin metabolism also appeared defective in some patients with low baseline and low accumulated levels of 5-HIAA after probenecid. Taken together with other clinical features of this disease, the results suggest an underlying disorder of dopamine and serotonin metabolism in Tourette syndrome.

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Seifert WE Jr, Foxx JL, Butler IJ. Ann Neurol. 1980 Jul; 8(1):38-42.
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Cited by 3 PubMed Central articles

A controlled study of Tourette syndrome-Revisited: A reply to the letter of Pauls et al. [Am J Hum Genet. 1988]
A controlled study of Tourette syndrome-Revisited: A reply to the letter of Pauls et al.
Comings DE, Comings BG. Am J Hum Genet. 1988 Aug; 43(2):209-17.
PET studies of the presynaptic and postsynaptic dopaminergic system in Tourette's syndrome. [J Neurol Neurosurg Psychiatry....]
PET studies of the presynaptic and postsynaptic dopaminergic system in Tourette's syndrome.
Turjanski N, Sawle GV, Playford ED, Weeks R, Lammerstma AA, Lees AJ, Brooks DJ. J Neurol Neurosurg Psychiatry. 1994 Jun; 57(6):688-92.
Review A controlled study of Tourette syndrome. VII. Summary: a common genetic disorder causing disinhibition of the limbic system. [Am J Hum Genet. 1987]
Review A controlled study of Tourette syndrome. VII. Summary: a common genetic disorder causing disinhibition of the limbic system.
Comings DE. Am J Hum Genet. 1987 Nov; 41(5):839-66.

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