The FASTCORE Family: For the Fast Reconstruction of Compact Context-Specific Metabolic Networks Models

Methods Mol Biol. 2018:1716:101-110. doi: 10.1007/978-1-4939-7528-0_4.

Abstract

The FASTCORE family is a family of algorithms that are mainly used to build context-specific models but can also be applied to other tasks such as gapfilling and consistency testing. The FASTCORE family has very low computational demands with running times that are several orders of magnitude lower than its main competitors. Furthermore, the models built by the FASTCORE family have a better resolution power (defined as the ability to capture metabolic variations between different tissues, cell types, or contexts) than models from other algorithms.

Keywords: Algorithm; Constraint-based modeling; Context-specific; FBA; Metabolic modeling; Microarray; omics data integration.

MeSH terms

  • Algorithms
  • Animals
  • Computational Biology / methods*
  • Humans
  • Metabolic Networks and Pathways*
  • Models, Biological