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Nature. 1989 Mar 16;338(6212):225-8.

Structure of tumour necrosis factor.

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  • 1Laboratory of Molecular Biophysics, Oxford, UK.

Abstract

Tumour necrosis factor is a trimeric molecule, each subunit of which consists of an antiparallel beta-sandwich. Individual subunits from the trimer by a novel edge-to-face packing of beta-sheets. A comparison of the subunit fold with that of other proteins reveals a remarkable similarity to the 'jelly-roll' structural motif characteristic of viral coat proteins.

PMID:
2922050
[PubMed - indexed for MEDLINE]
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