Renal-Clearable PEGylated Porphyrin Nanoparticles for Image-guided Photodynamic Cancer Therapy

Liang Cheng; Dawei Jiang; Anyanee Kamkaew; Hector F Valdovinos; Hyung-Jun Im; Liangzhu Feng; Christopher G England; Shreya Goel; Todd E Barnhart; Zhuang Liu; Weibo Cai

doi:10.1002/adfm.201702928

Renal-Clearable PEGylated Porphyrin Nanoparticles for Image-guided Photodynamic Cancer Therapy

Adv Funct Mater. 2017 Sep 13;27(34):1702928. doi: 10.1002/adfm.201702928. Epub 2017 Jul 26.

Authors

Liang Cheng^{1

2}, Dawei Jiang², Anyanee Kamkaew^{2

3}, Hector F Valdovinos⁴, Hyung-Jun Im², Liangzhu Feng¹, Christopher G England⁴, Shreya Goel⁵, Todd E Barnhart⁴, Zhuang Liu¹, Weibo Cai^{2

4

5}

Affiliations

¹ Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China.
² Departments of Radiology, University of Wisconsin-Madison, Wisconsin 53705, United States.
³ School of Chemistry, Institute of Science, Suranaree Institute of Science, Nakhon Ratchasima 30000, Thailand.
⁴ Department of Medical Physics, University of Wisconsin-Madison, Wisconsin 53705, United States.
⁵ Materials Science Program, University of Wisconsin-Madison, Wisconsin 53705, United States.

Abstract

Noninvasive dynamic positron emission tomography (PET) imaging was used to investigate the balance between renal clearance and tumor uptake behaviors of polyethylene glycol (PEG)-modified porphyrin nanoparticles (TCPP-PEG) with various molecular weights. TCPP-PEG_10K nanoparticles with clearance behavior would be a good candidate for PET image-guided photodynamic therapy.

Keywords: Dynamic PET imaging; Fluorescence imaging; Photodynamic therapy; Renal clearance; TCPP-PEG nanoparticles.

Abstract

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