Tuning Biased GPCR Signaling for Physiological Gain

Skylar Spangler; Michael R Bruchas

doi:10.1016/j.cell.2017.10.046

Tuning Biased GPCR Signaling for Physiological Gain

Cell. 2017 Nov 16;171(5):989-991. doi: 10.1016/j.cell.2017.10.046.

Authors

Skylar Spangler¹, Michael R Bruchas²

Affiliations

¹ Department of Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
² Department of Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Washington University Pain Center, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: bruchasm@wustl.edu.

PMID: 29149613
DOI: 10.1016/j.cell.2017.10.046

Abstract

Effective and safe doses of opiate painkillers, like morphine, can be limited by respiratory depression. Schmid et al. (2017) now present a quantitative method to design ligands and correlate GPCR signaling bias to the dose separation between therapeutic and adverse effects in animals.

Publication types

Comment

MeSH terms

Analgesics, Opioid*
Animals
Ligands
Morphine
Signal Transduction / drug effects*

Substances

Analgesics, Opioid
Ligands
Morphine