Bond with Me If You Can! Natural Product, Covalent Ligand, and Reactivity-Based Probe Compete for Cysteine in PP2A Complex

Douglas S Johnson; Jaimeen D Majmudar

doi:10.1016/j.chembiol.2017.10.013

Bond with Me If You Can! Natural Product, Covalent Ligand, and Reactivity-Based Probe Compete for Cysteine in PP2A Complex

Cell Chem Biol. 2017 Nov 16;24(11):1317-1318. doi: 10.1016/j.chembiol.2017.10.013.

Authors

Douglas S Johnson¹, Jaimeen D Majmudar²

Affiliations

¹ Discovery Network Chemical Biology, Pfizer Worldwide Research & Development, Cambridge, MA 02139, USA. Electronic address: doug.johnson@pfizer.com.
² Discovery Network Chemical Biology, Pfizer Worldwide Research & Development, Cambridge, MA 02139, USA.

PMID: 29149589
DOI: 10.1016/j.chembiol.2017.10.013

Abstract

In this issue of Cell Chemical Biology, Grossman et al. (2017) disclose a chemoproteomics-enabled strategy to identify the cysteine-reactive target(s) of the anti-cancer natural product withaferin A and then screen a cysteine-reactive fragment library to discover a covalent ligand for the same target.

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MeSH terms

Biological Products*
Cysteine*
Ligands

Substances

Biological Products
Ligands
Cysteine