Effect of alpha- and selective beta-blockade for hypertension control on plasma lipoproteins, apoproteins, lipoprotein subclasses, and postprandial lipemia

Am J Med. 1989 Jan 23;86(1B):26-31. doi: 10.1016/0002-9343(89)90125-3.

Abstract

Fourteen male patients (mean age +/- SD, 52 +/- 11 years) with a history of hypertension (systolic blood pressure, 148 +/- 10 mm Hg; diastolic blood pressure, 99 +/- 2 mm Hg) were enrolled in a cross-over trial of prazosin and atenolol, with a minimum of eight weeks of treatment with each drug. Measures of lipoprotein metabolism included levels of: total plasma cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and high-density lipoprotein2 cholesterol. Lipoprotein mass was measured by analytical ultracentrifugation in low-density to very low-density lipoprotein flotation rate intervals of 0 to 12, 12 to 20, and 20 to 400, and high-density lipoprotein flotation rate intervals of 0 to 3.5 and 3.5 to 9.0. Apolipoproteins A1 and B, postheparin lipoprotein and hepatic lipase activities, and magnitude of postprandial lipemia also were determined. Mass of intermediate-density lipoproteins (flotation rate, 12 to 20) was significantly lower (p = 0.05) following prazosin therapy compared with atenolol therapy. Other lipid parameters, including triglycerides and low- and high-density lipoprotein cholesterol, were not significantly different for the two drug treatments.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Apoproteins / blood*
  • Atenolol / therapeutic use*
  • Blood Pressure / drug effects
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Eating
  • Humans
  • Hypertension / blood*
  • Hypertension / drug therapy
  • Hypertension / physiopathology
  • Lipids / blood*
  • Lipoproteins / blood*
  • Male
  • Middle Aged
  • Prazosin / therapeutic use*
  • Triglycerides / blood

Substances

  • Apoproteins
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Lipids
  • Lipoproteins
  • Triglycerides
  • Atenolol
  • Cholesterol
  • Prazosin