Recent studies have uncovered that nitric oxide (NO) signaling is largely conducted by S-nitrosylation, involving >3000 proteins. The nitrosyl group could then travel further by transnitrosylation or be secreted, enabling regulation of the whole tissue. A subset of proteins are constitutively S-nitrosylated, playing roles in the regulation of tissue homeostasis.
Keywords: S-nitrosylation; homeostasis; nitric oxide; transnitrosylation.
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