Proc Natl Acad Sci U S A. 1989 Jan;86(1):262-6.

Insect immunity: isolation from immune blood of the dipteran Phormia terranovae of two insect antibacterial peptides with sequence homology to rabbit lung macrophage bactericidal peptides.

Lambert J, Keppi E, Dimarcq JL, Wicker C, Reichhart JM, Dunbar B, Lepage P, Van Dorsselaer A, Hoffmann J, Fothergill J, et al.

Source

Unité Associée au Centre National de la Recherche Scientifique, Laboratoire de Biologie Générale, Strasbourg, France.

Erratum in

Proc Natl Acad Sci U S A 1989 May;86(9):3321.

Abstract

We have isolated from the hemolymph of immunized larvae of the dipteran insect Phormia terranovae two peptides that are selectively active against Gram-positive bacteria. They are positively charged peptides of 40 residues containing three intramolecular disulfide bridges and differ from one another by only a single amino acid. These peptides are neither functionally nor structurally related to any known insect immune response peptides but show significant homology to microbicidal cationic peptides from mammalian granulocytes (defensins). We propose the name "insect defensins" for these insect antibiotic peptides.

PMID:: 2911573; [PubMed - indexed for MEDLINE]
PMCID:: PMC286444

Free PMC Article

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Insect immunity: expression of the two major inducible antibacterial peptides, defensin and diptericin, in Phormia terranovae. [EMBO J. 1990]
Insect immunity: expression of the two major inducible antibacterial peptides, defensin and diptericin, in Phormia terranovae.
Dimarcq JL, Zachary D, Hoffmann JA, Hoffmann D, Reichhart JM. EMBO J. 1990 Aug; 9(8):2507-15.
Insect immunity. Purification and characterization of a family of novel inducible antibacterial proteins from immunized larvae of the dipteran Phormia terranovae and complete amino-acid sequence of the predominant member, diptericin A. [Eur J Biochem. 1988]
Insect immunity. Purification and characterization of a family of novel inducible antibacterial proteins from immunized larvae of the dipteran Phormia terranovae and complete amino-acid sequence of the predominant member, diptericin A.
Dimarcq JL, Keppi E, Dunbar B, Lambert J, Reichhart JM, Hoffmann D, Rankine SM, Fothergill JE, Hoffmann JA. Eur J Biochem. 1988 Jan 15; 171(1-2):17-22.
Insect immunity. Isolation from a coleopteran insect of a novel inducible antibacterial peptide and of new members of the insect defensin family. [J Biol Chem. 1991]
Insect immunity. Isolation from a coleopteran insect of a novel inducible antibacterial peptide and of new members of the insect defensin family.
Bulet P, Cociancich S, Dimarcq JL, Lambert J, Reichhart JM, Hoffmann D, Hetru C, Hoffmann JA. J Biol Chem. 1991 Dec 25; 266(36):24520-5.
Review The inducible antibacterial peptides of dipteran insects. [Res Immunol. 1990]
Review The inducible antibacterial peptides of dipteran insects.
Hoffmann JA, Hoffmann D. Res Immunol. 1990 Nov-Dec; 141(9):910-8.
Review Antibacterial peptides: key components needed in immunity. [Cell. 1991]
Review Antibacterial peptides: key components needed in immunity.
Boman HG. Cell. 1991 Apr 19; 65(2):205-7.

See reviews... See all...

Cited by 37 PubMed Central articles

Transcriptome of the plant virus vector Graminella nigrifrons, and the molecular interactions of maize fine streak rhabdovirus transmission. [PLoS One. 2012]
Transcriptome of the plant virus vector Graminella nigrifrons, and the molecular interactions of maize fine streak rhabdovirus transmission.
Chen Y, Cassone BJ, Bai X, Redinbaugh MG, Michel AP. PLoS One. 2012; 7(7):e40613. Epub 2012 Jul 12.
Review Epithelial antimicrobial defence of the skin and intestine. [Nat Rev Immunol. 2012]
Review Epithelial antimicrobial defence of the skin and intestine.
Gallo RL, Hooper LV. Nat Rev Immunol. 2012 Jun 25; 12(7):503-16. Epub 2012 Jun 25.
Molecular and functional characterization of a c-type lysozyme from the Asian corn borer, Ostrinia furnacalis. [J Insect Sci. 2009]
Molecular and functional characterization of a c-type lysozyme from the Asian corn borer, Ostrinia furnacalis.
Wang WX, Wang YP, Deng XJ, Dang XL, Tian JH, Yi HY, Li YF, He XF, Cao Y, Xia QY, et al. J Insect Sci. 2009; 9:17.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Insect immunity: isolation from immune blood of the dipteran Phormia terranovae ...
Insect immunity: isolation from immune blood of the dipteran Phormia terranovae of two insect antibacterial peptides with sequence homology to rabbit lung macrophage bactericidal peptides.
Proc Natl Acad Sci U S A. 1989 Jan ;86(1):262-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: