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J Gerontol. 1989 Jan;44(1):B20-2.

Evidence for the glycation hypothesis of aging from the food-restricted rodent model.

Author information

  • 1Department of Physiology, University of Texas Health Science Center, San Antonio.

Abstract

Glucose has been proposed as a mediator of aging processes by means of glycation reactions resulting in advanced glycosylation end-products, thereby altering protein and DNA function. Testing this provocative concept has a high priority in gerontologic research. In this study, food restriction of rats--a procedure which markedly retards aging processes--was used to test the glycation hypothesis. Food-restricted rats were found to have a sustained plasma glucose concentration and percentage glycosylation of hemoglobin significantly lower than those of ad libitum fed rats. These findings are consistent with and provide support for the glycation hypothesis.

PMID:
2910985
[PubMed - indexed for MEDLINE]
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