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J Exp Med. 1989 Jan 1;169(1):345-50.

Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer.

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  • 1Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.

Abstract

Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene. These genes are arranged in cis position on the DR3DQw2 haplotype and in trans position in DR5DQw7/DR7DQw2 heterozygous individuals. Thus, most CD patients may share the same cis- or trans-encoded HLA-DQ alpha/beta heterodimer.

PMID:
2909659
[PubMed - indexed for MEDLINE]
PMCID:
PMC2189170
Free PMC Article
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