TYRP1 mRNA goes fishing for miRNAs in melanoma

Nat Cell Biol. 2017 Oct 31;19(11):1311-1312. doi: 10.1038/ncb3637.

Abstract

A variety of non-coding RNAs have been reported as endogenous sponges for cancer-modulating miRNAs. However, miRNA trapping by transcripts with protein-coding functions is less understood. The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16 on non-canonical miRNA response elements in melanoma, thereby promoting malignant growth.

MeSH terms

  • Animals
  • Cell Proliferation / genetics
  • Humans
  • Melanoma / genetics*
  • Membrane Glycoproteins / genetics*
  • MicroRNAs / genetics*
  • Oxidoreductases / genetics*
  • Tumor Suppressor Proteins / genetics

Substances

  • MIRN16 microRNA, human
  • Membrane Glycoproteins
  • MicroRNAs
  • Tumor Suppressor Proteins
  • Oxidoreductases
  • TYRP1 protein, human